MERRF SYNDROME

General
Ragged-red muscle fibers
Hearing
Sensorineural hearing loss
Metabolic Abnormality
Defect in translation of all mtDNA-encoded genes
Serum pyruvate or pyruvate and lactate elevated
Muscle
Muscle weakness
Neurologic Abnormality
Ataxia
Myoclonus epilepsy
Spasticity
Ocular
Myopathy