CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL

Cardiovascular
Increased sweating
Endocrine and/or Exocrine
Poor temperature regulation 
Gastrointestinal
Constipation
Hirschsprung disease
Poor feeding 
General
Hypoventilation occurs in the absence of primary neuromuscular, lung, or cardiac disease, or an identifiable brainstem lesion
Onset at birth 
Worsening of symptoms during sleep
Metabolic Abnormality
Chronic hypercapnia
Chronic hypoxemia
Decreased basal body temperature
Neoplasia
Ganglioneuroma
Tumors of the sympathetic nervous system
Neurologic Abnormality
Dysfunction of the autonomic nervous system
Ocular
Diminished pupillary light responses
Renal
Ganglioneuroblastoma
Neuroblastoma
Respiratory
Abnormal respiration due to defect in autonomic function
Alveolar hypoventilation
Decreased sensitivity to hypercapnia and hypoxemia
Normal respiratory rate
Periods of apnea
Shallow breathing (decreased tidal volume)