HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1

Abdomen
Abdomen pain
Cardiovascular
Diffuse vasculopathy
Malignant Hypertension
Reduced haptoglobin
Systemic Hypertension
Gastrointestinal
Colitis
Gastroenteritis
Nausea
Possible prodrome of diarrhea
Vomiting
General
Edema
Genitourinary
Anuria
Renal insufficiency
Hematologic
Burr cells
Hyperlipidemia
Microangiopathic hemolytic anemia
Reticulocytosis
Schistocytes
Thrombocytopenia
Thrombotic microangiopathy
Immunologic System
Activation of the complement system
Complement component consumption
Defective complement regulation
Some patients may have autoantibodies to factor H, resulting in functional factor H deficiency
Metabolic Abnormality
Decreased hemoglobin
Decreased serum C3
Decreased serum factor B
Decreased serum factor H
Decreased serum factor I
Fever
Increased blood urea nitrogen
Increased creatinine
Normal activity of von Willebrand factor-cleaving protease
Neurologic Abnormality
Cognitive decline
Coma
Dysphasia
Encephalopathy
Hemiparesis
Neurologic abnormalities
Seizures
Renal
Abnormal urinalysis
Elevated creatinine
Reduction glomerular filtration rate