Signs / Symptoms (20)
Craniofacial |
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Ocular dysmetria |
General |
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Onset after age 40 years |
Slow progression |
Neurologic Abnormality |
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Cerebellar atrophy |
Cortical and subcortical atrophy |
Decreased vibratory sense in the lower limbs |
Demyelination of the posterior and lateral columns of the spinal cord |
Dysarthria |
Extensor plantar responses |
Gait ataxia |
Limb ataxia |
Mixed axonal polyneuropathy |
Neuronal loss in the Purkinje cell layer of the cerebellar vermis |
Neuronal loss in the dentate nuclei |
Neuronal loss in the inferior olives |
Thinning of the cerebellopontine tracts |
Tremor |
Ocular |
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Slow saccades |
Performance |
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Hyperreflexia |
Mental retardation |