Signs / Symptoms (20)

Craniofacial
Ocular dysmetria

General
Onset after age 40 years
Slow progression

Neurologic Abnormality
Cerebellar atrophy
Cortical and subcortical atrophy
Decreased vibratory sense in the lower limbs
Demyelination of the posterior and lateral columns of the spinal cord
Dysarthria
Extensor plantar responses
Gait ataxia
Limb ataxia
Mixed axonal polyneuropathy
Neuronal loss in the Purkinje cell layer of the cerebellar vermis
Neuronal loss in the dentate nuclei
Neuronal loss in the inferior olives
Thinning of the cerebellopontine tracts
Tremor

Ocular
Slow saccades

Performance
Hyperreflexia
Mental retardation